Hubungan Kadar Soluble FMS-Like Tyrosine Kinase 1 (sFlt-1) Ibu Preeklampsia Dengan Berat Badan Lahir Bayi

Gusriani Sabrin, Wahida Sunardi, Nur Indah Noviyanti
  JOIM, pp. 91-100  


Soluble Fms like tyrosine kinase 1 (sFlt-1) is one of the markers that play a role in the pathogenesis of pregnancy induced hypertension. The aims of the research were to determine the relationship beteween sFlt-1 level and birth weight. The samples were preeclampsia inpartu consisting of 22 peopole,, and normal pregnancy women consisting of 18 people. Analytic observational study with cross sectional was conducted. The level of sFlt-1 was examined using ELISA. Statistic analysis used Kruskal Wallis test, One way Anova test and Pearson correlation test.The result indicate that the characteristics of research subject in preeclampsia group and control group do not have a significant difference (p>0.05).The negative linear relationship occured between sFlt-1 level with birth weight in preeclampsia (p=0,015). While, in the group of normal pregnancy was not available of the relationship either sFlt-1 level with birth weight (p>0.05).


sFlt-1, preeclampsia, birth weight.

Full Text:



Sibai BM. Preeclampsia as a cause of preterm and late preterm (near-term) births. In: Seminars in Perinatology. 2006. p. 16–9.

Airoldi J, Weinstein L. Clinical significance of proteinuria in pregnancy. Vol. 62, Obstetrical and Gynecological Survey. 2007. p. 117–24.

Poon LC, Nicolaides KH. Early Prediction of Preeclampsia. Obstet Gynecol Int. 2014;2014:1–11.

Muti M, Tshimanga M, Notion GT, Bangure D, Chonzi P. Prevalence of pregnancy induced hypertension and pregnancy outcomes among women seeking maternity services in Harare, Zimbabwe. BMC Cardiovasc Disord. 2015;15(1).

Sajith M, Nimbargi V, Modi A, Sumariya R. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. Int J pharma Sci Res. 2014;5(4):163–70.

POGI. PNPK Diagnosis dan Tatalaksana Preeklampsia. 2016;1–48.

Sivakumar S, Vishnu Bhat B, Badhe BA. Effect of pregnancy induced hypertension on mothers and their babies. Indian J Pediatr. 2007;74(7):623–5.

A.G. M, H. Y, J.M. K, L.R. O, J. Y, T.A.M. S, et al. Angiogenic biomarkers for prediction of maternal and neonatal complications in suspected preeclampsia. J Matern Neonatal Med [Internet]. 2012;25(12):2651–7. Available from:

Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24):2856–69.

Hagmann H, Thadhani R, Benzing T, Karumanchi SA, Stepan H. The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Vol. 58, Clinical Chemistry. 2012. p. 837–45.

Karumanchi SA, Bdolah Y. Hypoxia and sFlt-1 in preeclampsia: The “chicken-and-egg” question. Vol. 145, Endocrinology. 2004. p. 4835–7.

Maynard SE, Karumanchi SA. Angiogenic Factors and Preeclampsia. Semin Nephrol. 2011;31(1):33–46.

Ohshima M, Coq JO, Otani K, Hattori Y, Ogawa Y, Sato Y, et al. Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity. Sci Rep. 2016;6.

Goulopoulou S, Davidge ST. Molecular mechanisms of maternal vascular dysfunction in preeclampsia. Vol. 21, Trends in Molecular Medicine. 2015. p. 88–97.

L.A. R, N.N. H, N. S. Association between pregnancy induced hypertension and low birth weight; a population based case-control study. Asia-Pacific J Public Heal [Internet]. 2008;20(2):152–8. Available from:

Seyom E, Abera M, Tesfaye M, Fentahun N. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl Referral Hospital, Ethiopia. J Ovarian Res. 2015;8(1).

Xiong X, Fraser WD. Impact of pregnancy-induced hypertension on birthweight by gestational age. Paediatr Perinat Epidemiol. 2004;18(3):186–91.

P. P, S. A. Correlation between BMI and pregnancy outcome among postnatal mothers with pregnancy induced hypertension in selected hospitals Bangalore. Nitte Univ J Heal Sci [Internet]. 2015;5(1):62–7. Available from:


  • There are currently no refbacks.